Where do Windows shortcut keys work?
You can create hotkeys for shortcuts in many places within Windows. Below is what Microsoft lists as the locations that shortcuts work:
Windows Explorer looks in 4 places for hotkeys, these are read on startup. The hotkey is stored in the shortcut. Only hotkeys on shortcuts in the four locations are live.
Each shortcut, that has a hotkey, will execute if they exist in those directories (and after reboot).